Genetic Basis of Androgen Excess
Study Summary
This is a research project on a disorder called "Polycystic Ovary Syndrome" (PCOS). This is a common, but poorly understood, combination of problems in women who have too much androgen ("male hormone"). Women with this disorder often have irregular menstrual cycles, infertility, acne and/or excess body hair in addition to problems with the metabolism of fats and sugars related to diabetes. Drs. Anthony Caruso and Robert Rosenfield are asking women with elevated androgen levels or a diagnosis of PCOS to take part in this research study to determine the possible genetic basis for PCOS.
The study is a thorough study of PCOS performed at no charge. It requires an overnight stay and blood drawing for a glucose tolerance test, and tests of pituitary, ovary, and adrenal gland function and an ultrasound picture of the ovaries. There also is a return visit for a blood draw one month after the initial stay after taking a cortisone-like pill for four to seven days.
Participation Details
To be considered for the study, subjects must:
- Have an elevated testosterone level or a diagnosis of polycystic ovary syndrome
- Be between the ages of 18 and 40
- Be off birth control pills or patches for at least two months and off birth control injections for at least six months
- Not be pregnant or breast feeding/nursing
Study Leaders: Anthony Caruso, MD and Robert Rosenfield, MD
Department: Obstetrics and Gynecology, Pediatrics and Medicine
For more information, contact:
Deborah Walsh, MS, RN
5841 S. Maryland Ave., MC 5053
Chicago, IL 60637
(773) 702-6432
dwalsh@peds.bsd.uchicago.edu
IRB: #10116
