Inherited Genes in Primary Recurrent Miscarriage

This trial is supported by the National Institutes of Health.

Study Summary

Recurrent pregnancy loss is a prevalent health problem that affects many couples trying to establish a family. Preliminary evidence suggests that an increased sharing of genes (inherited substances responsible for our unique characteristics) among family members may impact the outcome of pregnancy. Further evidence is needed to determine whether increased sharing of certain genes is associated with pregnancy loss.

The purpose of this study is to examine the possible associations between various levels of shared genes among family members as a contributing factor in patients with a history of pregnancy loss.

Women who have been evaluated by Dr. Stephenson at the University of Chicago's Recurrent Pregnancy Loss Program for a history of recurrent pregnancy loss will be asked to participate prior to pregnancy and until six months after pregnancy. Research bloods will be obtained up to eight times. Cord blood and/or miscarriage tissue will be used, as well as mouthwash samples from the participant's partner and parents.

The benefits of participating in this trial include contributing to medical research designed to answer some very important questions about inherited factors and recurrent pregnancy loss.

Participation Details

Inclusion criteria for the study include:

• No successful prior pregnancies
• Three or more consecutive, unexplained miscarriages conceived with the same partner

Study Director: Mary D. Stephenson, MD, MSc
Department: Obstetrics and Gynecology, Section of Reproductive Endocrinology and Infertility

For more information, contact:
Patricia A. Schultz, RN, MHA
Recurrent Pregnancy Loss Research Office
University of Chicago
Department of Obstetrics and Gynecology
5841 S. Maryland Ave. (MC 2050)
Chicago, IL 60637
(773) 834-2106

IRB: #14675B