Does the Response to a Nasal Decongestant Test Predict the Outcome to Treatment of Seasonal Allergic Rhinitis with Nasonex?
Study Summary
About 40 percent of patients diagnosed with seasonal allergic rhinitis (hayfever) do not get an excellent response to intranasal steroids, like Nasonex.
Swelling in the nose occurs in seasonal allergic rhinitis. Spraying a topical (coats the surface) decongestant in the nose will shrink the swelling and improve airflow.
This research study is being done to see if we can predict with a simple “decongestant test” which subjects with allergic rhinitis will do well when treated with a steroid nasal spray.
Participation Details
- Males and females between 18 and 60 years of age in good health.
- History of grass, tree and/or ragweed allergic rhinitis.
- Positive skin or RAST test to grass, trees and/or ragweed antigen.
- Symptomatic at time of entry into study.
Interested subjects will come for a screening visit (lasting about 45 minutes) at which time they will undergo an allergy skin prick test and be questioned about their allergy history.
Eligible subjects will undergo a simple decongestant test (the nose will be sprayed with a decongestant and air flow will be measured) and then given a nasal steroid spray or a placebo (no active medication) spray to use for two weeks during their allergy season. They will be asked to fill out diary cards twice a day and will return for a final visit at the end of the two weeks.
Compensation may be $300.
Study Director: Robert Naclerio, MD
Department: Otolaryngology--Head and Neck Surgery
For more information, please contact:
Marcy deTineo, RN
5841 S. Maryland Avenue, MC 1035
Chicago, Il 60637
(773) 702-5889
mdetineo@surgery.bsd.uchicago.edu
IRB: #15624B
