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Babak Mokhlesi, MD, MSc

Professor of Medicine

Director, Sleep Disorders Center

Director, Sleep Medicine Fellowship Program

Dr. Babak Mokhlesi is a pulmonologist and an expert in sleep disorders. He treats patients with a wide variety of sleep disorders, ranging from respiratory disorders of sleep -- such as sleep apnea and obesity hypoventilation syndrome -- to non-respiratory sleep disorders including narcolepsy, restless legs syndrome, parasomnias, circadian rhythm disorders and insomnia. In his practice, Dr. Mokhlesi cares for patients in clinic as well as in the intensive care unit.

During the last few years, his research has focused on obstructive sleep apnea, with a specific focus on REM-related sleep-disordered breathing, perioperative complications in patients with sleep apnea, as well as best treatment strategies in patients with obesity hypoventilation syndrome. He is also interested in studying the impact of continuous positive airway pressure (CPAP) therapy on metabolic and cardiovascular outcomes in obstructive sleep apnea.

In addition to authoring several book chapters and articles, Dr. Mokhlesi is an associate editor for journal Thorax and the Journal of Clinical Sleep Medicine. He also serves on the editorial board of Chest.

Practice Locations

Duchossois Center for Advanced Medicine
5758 S. Maryland Avenue
Chicago, IL 60637

The University of Chicago Medicine
5841 S. Maryland Avenue
Chicago, IL 60637

150 E. Huron Street
Suite 900
Chicago, IL 60611

Year Started Practice


Board Certifications

Internal Medicine
Pulmonary Diseases
Critical Care Medicine
Sleep Medicine

Medical School

University of Monterrey

Internship & Residency

Weiss Memorial Hospital/University of Chicago Program B


Northwestern University, Chicago (Pulmonary & Critical Care Medicine)
Northwestern University, Chicago (Sleep Medicine)


American Academy of Sleep Medicine
American College of Chest Physicians
American Thoracic Society
Chicago Thoracic Society

Languages Spoken



Office Phone

(773) 702-9660

Office Fax

(773) 834-7068

Office Postal Address

Babak Mokhlesi, MD
The University of Chicago Medicine
5841 S. Maryland Avenue, MC 0999
Chicago, IL 60637

Physician Photo

Clinical Interests

  • Pulmonary and critical care medicine
  • Sleep disorders
  • Sleep medicine
  • Narcolepsy
  • Restless legs syndrome
  • Periodic limb movement disorder
  • Parasomnias
  • REM behavior disorder
  • Sleep walking
  • Sleep talking
  • Obstructive sleep apnea
  • Insomnia
  • Central sleep apnea
  • Obesity hypoventilation syndrome

Request an Appointment

Center for Advanced Medicine
Request an appointment online
or call UCM Connect at

150 E. Huron Street
Request an appointment online
or call (773) 834-4150

Physicians, contact the
Referring Physician Access Line
at 1-877-DOM-2730

Selected Publications

View a partial list of Dr. Mokhlesi's publications through the National Library of Medicine's PubMed online database.