Charles Rubin, MD

Associate Professor of Pediatrics

Director, Brain & Spinal Cord Tumor Program

Director, Community Care Program

An authority on childhood cancers, Dr. Charles Rubin has been overseeing the care of children for 25 years. He is a strong believer in educating patients and their families--and in involving them in the decision process in a meaningful way. Dr. Rubin works to find every option for the patient, and then carefully chooses the best option for that patient.

Dr. Rubin has worked to uncover the genetic basis for cancer through laboratory research aimed at identifying and dissecting the chromosomal abnormalities that occur in childhood cancers. An active researcher, Dr. Rubin is involved in clinical trials for childhood cancer treatments. He has published numerous articles in top medical journals on his work in leukemia, lymphoma, retinoblastoma, and other diseases.

While he treats all childhood cancers, Dr. Rubin is especially interested in brain tumors, eye tumors (retinoblastoma), tumors occurring in children with genetic syndromes, and bone marrow transplantation.

Dr. Rubin collaborates with physicians around the nation through the Children’s Oncology Group, the Pediatric Blood and Bone Marrow Consortium, and the National Cancer Institute.

Practice Locations

Duchossois Center for Advanced Medicine
5758 S. Maryland Avenue
Chicago, IL 60637

The University of Chicago Medicine Comer Children's Hospital
5721 S. Maryland Avenue
Chicago, IL 60637

University of Chicago Pediatric Specialists
Medical Office Building II
120 Spalding Drive, Suite 200
Naperville, IL 60540

University of Chicago Medicine Comprehensive Cancer Center
1850 Silver Cross Blvd.
New Lenox, IL 60451

University of Chicago Pediatric Specialists
8528 Broadway
Merrillville, IN 46410

Year Started Practice


Board Certifications

Pediatric Hematology/Oncology
Medical Genetics

Medical School

Tufts University School of Medicine

Internship and Residency

Children's Hospital, Philadelphia


University of Minnesota Medical Center, Minneapolis
The University of Chicago Medicine


American Academy of Pediatrics
American Society of Pediatric Hematology/Oncology

Language Spoken



Office Phone

(773) 702-6808

Office Fax

(773) 702-9881

Office Postal Address

Charles Rubin, MD
The University of Chicago Medicine
5841 S. Maryland Avenue, MC 4060
Chicago, IL 60637

Physician Photo

Clinical Interests

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Learn More About Dr. Rubin

William Dawes was diagnosed with a rare spinal cord tumor at the age of 7. Now, a decade later, the college freshman is pursuing his dreams as Dr. Rubin cheers him on. Read the story.

The astrocytoma in Daniel’s brain was inoperable, and growing in a particularly critical location. Dr. Rubin led an innovative, team-based treatment plan that successfully stopped the tumor from growing and threatening Daniel’s well-being. Read his story.

When Steve and Laura's daughter was diagnosed with acute lymphoblastic leukemia, they reached out to the University of Chicago Medicine and were immediately comforted by Dr. Rubin’s treatment philosophy.

Selected Publications

View a partial list of Dr. Rubin's publications through the National Library of Medicine's PubMed online database.