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Daniel Appelbaum, MD

Professor of Radiology

Director, Nuclear Medicine and PET Imaging

Daniel Appelbaum, MD, is both a radiologist and nuclear medicine physician. He has expertise in the full spectrum of nuclear/molecular imaging, specializing in oncologic, neurologic, cardiac, and positron emission tomographic (PET and PET/CT) applications. Dr. Appelbaum and his colleagues offer a full array of both diagnostic and therapeutic nuclear exams and procedures for adults and children at the University of Chicago.

Dr. Appelbaum conducts nuclear and molecular imaging research in the basic science and clinical settings. His current work involves development of a novel brain imaging agent for multiple sclerosis, as well as a novel metabolic catalyst to augment tumor detection with PET imaging. Other interests include developing new strategies for using computer-aided diagnosis (CAD) in nuclear medicine, work for which he has been awarded a patent in artificial intelligence (AI). The section he leads is involved in several oncology PET/CT clinical trials that monitor how patients respond to therapy. Dr. Appelbaum chairs the University of Chicago Radioactive Drug Research Advisory Committee (RADRAC).

An active educator, Dr. Appelbaum accepts many lecture invitations on nuclear and PET imaging at hospitals and medical meetings worldwide. He is a longstanding member of the national Society of Nuclear Medicine Committee on Education. He also recently published a textbook (Nuclear Medicine RadCases) designed as a comprehensive review of his field.

Practice Locations

The University of Chicago Medicine
5841 S. Maryland Avenue
Chicago, IL 60637

Duchossois Center for Advanced Medicine
5758 S. Maryland Avenue
Chicago, IL 60637

Year Started Practice


Board Certifications

Nuclear Medicine

Medical School

Mt. Sinai School of Medicine

Internship and Residency

The University of Chicago Medicine


Washington University School of Medicine, St. Louis


Radiological Society of North America
Society of Nuclear Medicine

Language Spoken



Office Phone

(773) 702-2012

Office Fax

(773) 702-1161

Office Postal Address

Daniel Appelbaum, MD
The University of Chicago Medicine
5841 S. Maryland Avenue, MC 2026
Chicago, IL 60637

Physician Photo

Clinical Interests

  • Radiology
  • Nuclear medicine
  • PET/CT imaging
  • Nuclear cardiology
  • Computer-aided diagnosis
  • Neurology

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Read More About Dr. Appelbaum

Dr. Appelbaum is an associate investigator in the University of Chicago Comprehensive Cancer Center.

Selected Publications

View a partial list of Dr. Appelbaum's publications through the National Library of Medicine's PubMed online database.