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Daniel H. Gruenstein, MD

Associate Professor of Pediatrics

Chief, Section of Pediatric Cardiology

Director, Pediatric Catheterization Lab

Co-Director, Chicago Pediatric Heart Center

Daniel H. Gruenstein, MD, cares for infants, children, teens and adults with congenital heart disease – abnormalities that affect the structure and function of a patient's heart. He specializes in interventional cardiology, including intravascular stent placement, valve implantation and hybrid cardiac catheterization procedures.

Dr. Gruenstein's research focuses on innovations in cardiac device development. He serves as the primary investigator on several studies that test new devices in preclinical and FDA approved settings. In addition, Dr. Gruenstein was one of 7 clinicians nationwide invited by the Society for Cardiovascular Angiography & Intervention to participate in the design and creation of a biodegradable stent for pediatric patients. He holds several provisional patents for his work.

A devoted educator, Dr. Gruenstein mentors medical students, residents and fellows in interventional cardiology. As one of only five instructors, Dr. Gruenstein trains approximately 20 percent of all cardiologists in the United States who use the Amplatzer Atrial Septal Occluder Device to treat atrial septal defects (holes in the wall between the upper chambers of the heart). He has directed several national hands-on workshops for adult and pediatric interventional cardiologists, teaching advanced therapeutic techniques.

Dr. Gruenstein has made significant contribution to the medical literature, publishing abstracts, peer-reviewed articles, book chapters and more on key topics in pediatric cardiology. In addition, he was a founding member and the inaugural president of the Pediatric/Congenital Interventional Cardiology Early-career Society (PICES), an international organization that promotes early faculty development and performs multi-center studies.

The recipient of numerous national awards, Dr. Gruenstein has been recognized by patients, students and peers alike. He has been honored with the Patients' Choice Award and Compassionate Doctor Award, and has been named to the list of Best Doctors in America by Best Doctors, Inc.

Practice Location

The University of Chicago Medicine
Comer Children’s Hospital
5721 S. Maryland Avenue
Chicago, IL 60637

DuPage Medical Group
1801 S. Highland Avenue, Suite 130
Lombard, IL 60148

Year Started Practice


Board Certifications

Pediatric Cardiology
Adult Congenital Heart Disease

Medical School

University of Cincinnati College of Medicine

Internship and Residency

Cincinnati Children's Hospital (pediatrics)


Cincinnati Children's Hospital (pediatric cardiology)


Society for Cardiovascular Angiography & Intervention, Fellow

Languages Spoken


Office Phone

(773) 702-6172

Office Fax

(773) 702-2319

Office Postal Address

Daniel H. Gruenstein, MD
The University of Chicago Medicine
5841 S. Maryland Avenue, MC 4051
Chicago, IL 60637

Physician Photo

Clinical Interests

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More About Dr Gruenstein

In honor of Heart Month, Dr. Gruenstein shares advice on how to be a good caretaker of your heart.

Selected Publications

View a partial list of Dr. Gruenstein's publications through the National Library of Medicine's PubMed online database.