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Eugene B. Chang, MD

Martin Boyer Professor of Medicine

Associate Section Chief for Research

Dr. Eugene Chang has been studying host-microbial interactions of the intestine, particularly in defining communication signals/pathways that are involved in maintaining intestinal homeostasis. These studies are also aimed at better understanding how perturbations or types of enteric flora contribute to the development of digestive diseases, especially inflammatory bowel diseases (IBD). As part of his research, Dr. Chang has defined several novel mechanisms and mediators of action of probiotic organisms that are currently being developed as therapeutic agents. One of the major actions of the enteric microbes is the maintenance of intestinal, epithelial heat shock proteins inherently important for enhancing cellular protection against immune/inflammatory stress, inhibiting apoptosis, and suppressing intestinal inflammation.

In addition, Dr. Chang is interested in the study of intestinal epithelial biology and pathobiology. His investigations include studies of the function and regulation of apical membrane Na-H exchangers (NHEs) that are major mediators of Na absorption by the intestine. He has been particularly interested in defining adaptor proteins involved in membrane trafficking of NHEs and functional coupling with other membrane transporters. He is also investigating the acute and chronic effects of immune and inflammatory mediators on epithelial barrier and transport functions.

Dr. Chang's laboratory is developing serological and tissue biomarkers predictive of risk for colorectal, hepatocellular, and esophageal cancers.

Practice Locations

The University of Chicago Medicine
5841 S. Maryland Avenue
Chicago, IL 60637

Center for Advanced Medicine
5758 S. Maryland Avenue
Chicago, IL 60637

Year Started Practice


Board Certifications

Internal Medicine

Medical School

University of Chicago Pritzker School of Medicine

Internship, Residency, and Fellowship

The University of Chicago Medicine


American Gastroenterological Association
American Society of Clinical Investigation
Association of American Physicians
Federation of American Societies for Experimental Biology
Gastroenterology Research Group

Language Spoken



Office Phone

(773) 702-6458

Office Fax

(773) 702-2281

Office Postal Address

Eugene Chang, MD
The University of Chicago Medicine
5841 S. Maryland Avenue, MC 6084
Chicago, IL 60637

Physician Photo

Clinical Interests

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Read More About Dr. Chang

In this article from Medicine on the Midway, read about how Dr. Chang's research studying the ecosystem within our bodies (PDF) may redefine how physicians approach infectious diseases.

Dr. Chang is the director of the Digestive Diseases Research Core Center.

Selected Publications

View a partial list of Dr. Chang's publications through the National Library of Medicine's PubMed online database.