Jeffrey I. Frank, MD

Professor of Neurology and Surgery

Director, Neuromedical/Neurosurgical Intensive Care

Dr. Jeffrey Frank is an internationally recognized leader in the field of neurointensive care and vascular neurology. At the University of Chicago, he has built one of the most reputable neurointensive care programs in the country.

He has been a pioneer in the clinical research area of life-threatening brain-swelling after stroke and was the lead principal investigator for a National Institute of Neurological Disorders and Stroke (NINDS)-sponsored multi-center clinical trial to determine the effectiveness of surgical decompression for brain swelling after stroke. The unique medical treatment protocols from that trial led to the lowest mortality for this severe type of stoke than ever reported in the literature and led to other pivotal trials that have changed the landscape of the treatment for this severe stroke.

In addition, Dr. Frank is a world expert in the area of brain death and has done provocative research on the physiology of brain death, variability of brain death policies and practice, and new approaches to the education of physicians on brain death. He is a leader on several national committees that are spearheading important changes to improve uniformity of policies, practice and education regarding brain death.

His clinical research program focuses on:

  • Neurological prognostication
  • Brain death
  • Brain swelling from stroke and other causes
  • Intracranial hypertension
  • Acute ischemic stroke
  • Intracerebral hemorrhage

Beyond his local leadership in building the neurocritical care program and comprehensive stroke program, Dr. Frank has been an instrumental national leader in the areas of neurocritical care and vascular neurology as chairman of the Critical Care and Emergency Neurology Section of the American Academy of Neurology, chairman of the Early Career Committee of the American Stroke Association, a founder and executive committee member of the Neurocritical Care Society, and an examiner for the American Board of Psychiatry and Neurology.

Practice Location

Duchossois Center for Advanced Medicine
5758 S. Maryland Avenue
Chicago, IL 60637

Year Started Practice


Board Certification


Medical School

Southern Illinois University School of Medicine


Memorial Medical Center, Springfield, IL


Northwestern University, Chicago


Harvard and Massachusetts General Hospital, Boston


American Academy of Neurology
American Stroke Association
Neurocritical Care Society

Language Spoken



Office Phone

(773) 834-4602

Office Fax

(773) 834-4612

Office Postal Address

Jeffrey Frank, MD
The University of Chicago Medicine
5841 S. Maryland Avenue, MC 2030
Chicago, IL 60637

Physician Photo

Clinical Interests

  • Neurology
  • Neurocritical care
  • Stroke
  • Intracerebral hemorrhage
  • Subarachnoid hemorrhage
  • Hemicraniectomy
  • Cerebral edema
  • Brain swelling
  • Neurological prognostication
  • Brain death
  • Acute liver failure associated with brain swelling
  • Guillain Barre Syndrome
  • Myasthenia gravis crisis
  • Acute disseminated encephalomyelitis

Request an appointment online
or call UCM Connect at

Read More About Dr. Frank

Learn how Dr. Frank and his colleagues organized a unique training session to prepare physicians for the complex and difficult call to diagnose brain death.

Read a PDF of "U of C to Open Dedicated Neurointensive Care Unit" -- an article that appeared in Clinical Comment, the medical center's newsletter for physicians.

Selected Publications

View a partial list of Dr. Frank's publications through the National Library of Medicine's publication database.