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Jeffrey B. Matthews, MD

Dallas B. Phemister Professor of Surgery

Chair, Department of Surgery

Dr. Jeffrey B. Matthews is a gastrointestinal surgeon and leading authority on the surgical treatment of diseases of the pancreas, bile ducts, and liver. He is highly skilled in the treatment of acute and chronic pancreatitis, and is one of a handful of surgeons in the nation who has expertise in islet autotransplantation, a treatment that prevents the development of diabetes after surgery for pancreatitis. He also has vast experience in bile duct reconstruction and complex reoperative gastrointestinal surgery.

Dr. Matthews has held several leadership positions during his distinguished career. Currently, he serves as senior director of the American Board of Surgery and president of the Society for Surgery of the Alimentary Tract.

Dr. Matthews' laboratory research explores the fundamental mechanisms used by epithelial tissues to regulate secretion--which goes awry in several diseases, including cystic fibrosis and many types of diarrhea. This research has received long-term support from the National Institutes of Health.

An accomplished author, Dr. Matthews has published over 150 original articles, chapters and editorials. He serves on the editorial board of 11 prestigious surgical and scientific journals and is currently associate editor of the Journal of Gastrointestinal Surgery.

Dr. Matthews is dedicated to teaching and mentoring medical students and new physicians, and has received awards for excellence in teaching. A popular speaker, Dr. Matthews is frequently invited to lecture at universities and medical conferences across the United States and abroad.

Practice Locations

The University of Chicago Medicine
5841 S. Maryland Avenue
Chicago, IL 60637

Center for Advanced Medicine
5758 S. Maryland Avenue
Chicago, IL 60637

Year Started Practice


Board Certification


Medical School

Harvard Medical School

Internship and Residency

Beth Israel Hospital (Harvard Medical School), Boston


University of Bern, Switzerland (Hepatobiliary Surgery)
Brigham and Women's Hospital, Boston (Pathology)


American Association for the Advancement of Science
American Board of Surgery
American College of Surgeons
American Gastroenterological Association
American Hepato-Pancreato-Biliary Association
American Medical Association
American Pancreatic Association
American Physiological Society
American Society for Bariatric Surgery
American Society for Clinical Investigation
American Surgical Association
Association for Academic Surgery
Association for Surgical Education
Gastroenterology Research Group
The Halsted Society
International Association of Pancreatology
Massachusetts Medical Society
Society for Surgery of the Alimentary Tract
Society for Surgical Chairs
Society of Clinical Surgery
Society of University Surgeons
Surgical Biology Club

Languages Spoken


Office Phone

(773) 702-0881

Office Fax

(773) 702-2140

Office Postal Address

Jeffrey Matthews, MD
The University of Chicago Medicine
5841 S. Maryland Avenue, MC 5029
Chicago, IL 60637

Physician Photo

Clinical Interests

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Selected Publications

Worrell RT, Merk L, Matthews JB. Ammonium transport in the colonic crypt cell line, T84: Role for Rhesus Glycoproteins and NKCC1. Am J Physiol Gastrointest Liver Physiol 2007 Nov 21 [Epub ahead of print]

Nair RR, Lowy AM, McIntyre B, Sussman JJ, Matthews JB, Ahmad SA. Fistulojejunostomy for the management of refractory pancreatic fistula. Surgery. 2007 Oct; 142(4):636-42.

Ahmad SA, Wray C, Rilo HL, Choe KA, Gelrud A, Howington JA, Lowy AM, Matthews JB. Chronic pancreatitis: recent advances and ongoing challenges. Curr Probl Surg. 2006 Mar;43(3):127-238.

Fischer DR, Matthews JB. Surgical peritonitis and other diseases of the peritoneum, mesentery, omentum, and diaphragm. In Sleisenger and Fordtran’s Gastrointestinal and Liver Disease (Feldman M et al, eds)., 8th ed., 2006.

Davis BR and Matthews JB. Diverticular disease of the colon. In, Therapy of Digestive Disorders (Wolfe MM, ed) 2nd edition, 2006.

Ahmad SA, Lowy AM, Wray CJ, D'Alessio D, Choe KA, James LE, Gelrud A, Matthews JB, Rilo HL. Factors associated with insulin and narcotic independence after islet autotransplantation in patients with severe chronic pancreatitis. J Am Coll Surg. 2005 Nov;201(5):680-7.

Robb BW, Matthews JB. Bile salt diarrhea. Curr Gastroenterol Rep. 2005 Oct;7(5):379-83.

Wray CJ, Ahmad SA, Matthews JB, Lowy AM. Surgery for pancreatic cancer: recent controversies and current practice. Gastroenterology. 2005;128(6):1626-41.

Paxton JH, Matthews JB. The cost effectiveness of laparoscopic versus open gastric bypass surgery. Obes Surg. 2005 Jan;15(1):24-34.
Ahmad SA, Lowy AM, McIntyre BC, Matthews JB. Pancreaticoduodenectomy. J Gastrointest Surg. 2005;9(1):138-43.

Ben-David K, Falcone RA Jr, Matthews JB. Diffuse pancreatic adenocarcinoma identified in an adult with annular pancreas. J Gastrointest Surg. 2004;8(5):565-8.

Rodriguez Rilo HL, Ahmad SA, D'Alessio D, Iwanaga Y, Kim J, Choe KA, Moulton JS, Martin J, Pennington LJ, Soldano DA, Biliter J, Martin SP, Ulrich CD, Somogyi L,Welge J, Matthews JB, Lowy AM. Total pancreatectomy and autologous islet cell transplantation as a means to treat severe chronic pancreatitis. J Gastrointest Surg. 2003;7(8):978-89.

Del Castillo IC, Fedor-Chaiken M, Song JC, Starlinger V, Yoo J, Matlin KS, Matthews JB. Dynamic regulation of Na(+)-K(+)-2Cl(-) cotransporter surface expression by PKC-{epsilon} in Cl(-)--secretory epithelia. Am J Physiol Cell Physiol. 2005 Nov;289(5):C1332-42.

Worrell RT, Best A, Crawford OR, Xu J, Soleimani M, Matthews JB. Apical ammonium inhibition of cAMP-stimulated secretion in T84 cells is bicarbonate dependent. Am J Physiol Gastrointest Liver Physiol. 2005;289(4):G768-78.

Worrell RT, Oghene J, Matthews JB. Ammonium effects on colonic Cl- secretion: anomalous mole fraction behavior. Am J Physiol Gastrointest Liver Physiol. 2004;286(1):G14-22.