Marion Hofmann-Bowman, MD, PhD
Associate Professor of Medicine
Marion Hofmann-Bowman, MD, PhD, is a cardiologist and known expert on vascular disease. An accomplished scientist, Dr. Hofmann’s laboratory investigates the molecular basis of blood vessel diseases. Through this research, funded by the National Institutes of Health (NIH) and other foundations, she hopes to define new treatment targets for atherosclerotic heart disease and aortic aneurysms. Her research focuses on aortic valve disease (bicuspid and calcific) and on thoracic aneurysms. She has written many articles on these subjects.
The University of Chicago Medicine
Center for Advanced Medicine
Year Started Practice
Ruprecht Karls University
North Shore University Hospital, Manhassat, NY
Heidelberg University Hospital, Germany
Columbia University Medical Center, New York
Additional Graduate Degree
PhD, Rupprecht Karls University, Heidelberg, Germany
American College of Cardiology
Office Postal Address
Marion Hofmann-Bowman, MD, PhD
Request an appointment online
Physicians, contact the
Read More About Dr. Hofmann-Bowman
Dr. Hofmann-Bowman is a member of the aortic specialty care team.
Ling Yan, Per Bjork, Randu Bantu, Joseph Gawdzik, Judy Earley, Gene Kim, Marion A. Hofmann Bowman. Beneficial effects of Quinoline-3-carboxamide (ABR-215757) on plaque stability in S100A12 transgenic ApoE null mice. Atherosclerosis. 2013, in press.
S. Chandra, R. Lang, J. Nicolarsen, E. Gayat, K. Spencer, M.A. Hofmann Bowman. Bicuspid Aortic Valve: Interracial Differences in Frequency and Aortic Dimensions. JACC-Cardiovascular Imaging. 2012 5 (10): 981-989.
Deepanjana Das, Joseph Gawdzik, Lisa Dellefave-Castillo, Elizabeth M. McNally, Aliya Husein, Jai Raman, Marion A. Hofmann Bowman. S100A12 expression in thoracic aortic aneurysm is associated with increased risk of dissection and perioperative complications. JACC. 2012 60 (8): 775-85.
MA Hofmann Bowman, J Gawdzik, U Bukhari, AN Husain, PT Toth, G Kim, J Earley, EM McNally. S100A12 in vascular smooth muscle accelerates vascular calcification in ApoE null mice by activating an osteogenic gene regulatory program. Arterioscler Thromb Vasc Biol. 2011 31;337-344.
MA Hofmann Bowman, J Wilk, A. Heydeman, G Kim, Y Zhang, J Rehman, J. Lodato, J Raman, EM McNally. S100A12 mediates aortic wall remodeling and aortic aneurysm. Circulation Research. 2010 106:145-154.
J. Gawdzik, L Mathew, G. Kim, T.S. Puri, MA Hofmann Bowman. Vascular remodeling and Arterial Calcification is directly mediated by S100A12 (EN-RAGE) in chronic kidney disease. American Journal Nephrology. 2011 33:250-259.
MA Hofmann Bowman, A. Heydeman, J Gawdzik, RA Shilling, B Camoretti-Mercado. Transgenic expression of S100A12 in smooth muscle induces structural airway abnormalities and limited lung inflammation in a mouse model of allergic inflammation. Clinical and Experimental Allergy. 2011 41: 878-889.
Marion A. Hofmann, Evanthia Lalla, Michelle Rye Gleason, Brigitte Kohl, Bonni Wolf, Walter Kiesel, David Stern, Ann Marie Schmidt. Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model. J Clin Invest. 2001 107 (6): 675-83.
Marion A. Hofmann, Steven Dury, Caifeng Fu, Wu Qu, Akihiko Taguchi, Yan Lu, Cecilia Avila, Neeraja Kambham, Timothy Slattery, Dale Beach, John Mc Clary, Mariko Nagashima, John Morser, Peter Nawroth, Markus F. Neurath, David Stern, and Ann Marie Schmidt. Rage mediates a novel proinflammatory axis: a central cell surface receptor for S 100/ Calgranulin polypeptides. Cell. 97 889-902, 1999.