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Marion Hofmann-Bowman, MD, PhD

Associate Professor of Medicine

Marion Hofmann-Bowman, MD, PhD, is a cardiologist and known expert on vascular disease. An accomplished scientist, Dr. Hofmann’s laboratory investigates the molecular basis of blood vessel diseases. Through this research, funded by the National Institutes of Health (NIH) and other foundations, she hopes to define new treatment targets for atherosclerotic heart disease and aortic aneurysms. Her research focuses on aortic valve disease (bicuspid and calcific) and on thoracic aneurysms. She has written many articles on these subjects.

Practice Locations

The University of Chicago Medicine
5841 S. Maryland Avenue
Chicago, IL 60637

Center for Advanced Medicine
5758 S. Maryland Avenue
Chicago, IL 60637

University of Chicago Medicine Center for Advanced Care at South Loop 
1101 S. Canal Street, Suite 201
Chicago, IL 60607

Year Started Practice


Board Certifications

Internal Medicine

Medical School

Ruprecht Karls University


North Shore University Hospital, Manhassat, NY


Heidelberg University Hospital, Germany
North Shore University Hospital, Manhassat, NY


Columbia University Medical Center, New York
The University of Chicago Medicine

Additional Graduate Degree

PhD, Rupprecht Karls University, Heidelberg, Germany


American College of Cardiology
American College of Physicians
American Heart Association
Central Society of Clinical Research

Languages Spoken



Office Phone

(773) 702-6153

Office Fax

(773) 702-8875

Office Postal Address

Marion Hofmann-Bowman, MD, PhD
The University of Chicago Medicine
5841 S. Maryland Avenue, MC 6080
Chicago, IL 60637

Physician Photo

Clinical Interests

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Read More About Dr. Hofmann-Bowman

Dr. Hofmann-Bowman was recently elected as an editorial board member for Arteriosclerosis, Thrombosis and Vascular Biology.

Dr. Hofmann-Bowman is a member of the aortic specialty care team.

Selected Publications

Ling Yan, Per Bjork, Randu Bantu, Joseph Gawdzik, Judy Earley, Gene Kim, Marion A. Hofmann Bowman. Beneficial effects of Quinoline-3-carboxamide (ABR-215757) on plaque stability in S100A12 transgenic ApoE null mice. Atherosclerosis. 2013, in press.

S. Chandra, R. Lang, J. Nicolarsen, E. Gayat, K. Spencer, M.A. Hofmann Bowman. Bicuspid Aortic Valve: Interracial Differences in Frequency and Aortic Dimensions. JACC-Cardiovascular Imaging. 2012 5 (10): 981-989.

Deepanjana Das, Joseph Gawdzik, Lisa Dellefave-Castillo, Elizabeth M. McNally, Aliya Husein, Jai Raman, Marion A. Hofmann Bowman. S100A12 expression in thoracic aortic aneurysm is associated with increased risk of dissection and perioperative complications. JACC. 2012 60 (8): 775-85.

MA Hofmann Bowman, J Gawdzik, U Bukhari, AN Husain, PT Toth, G Kim, J Earley, EM McNally. S100A12 in vascular smooth muscle accelerates vascular calcification in ApoE null mice by activating an osteogenic gene regulatory program. Arterioscler Thromb Vasc Biol. 2011 31;337-344.

MA Hofmann Bowman, J Wilk, A. Heydeman, G Kim, Y Zhang, J Rehman, J. Lodato, J Raman, EM McNally. S100A12 mediates aortic wall remodeling and aortic aneurysm. Circulation Research. 2010 106:145-154.

J. Gawdzik, L Mathew, G. Kim, T.S. Puri, MA Hofmann Bowman. Vascular remodeling and Arterial Calcification is directly mediated by S100A12 (EN-RAGE) in chronic kidney disease. American Journal Nephrology. 2011 33:250-259.

MA Hofmann Bowman, A. Heydeman, J Gawdzik, RA Shilling, B Camoretti-Mercado. Transgenic expression of S100A12 in smooth muscle induces structural airway abnormalities and limited lung inflammation in a mouse model of allergic inflammation. Clinical and Experimental Allergy. 2011 41: 878-889.

Marion A. Hofmann, Evanthia Lalla, Michelle Rye Gleason, Brigitte Kohl, Bonni Wolf, Walter Kiesel, David Stern, Ann Marie Schmidt. Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model. J Clin Invest. 2001 107 (6): 675-83.

Marion A. Hofmann, Steven Dury, Caifeng Fu, Wu Qu, Akihiko Taguchi, Yan Lu, Cecilia Avila, Neeraja Kambham, Timothy Slattery, Dale Beach, John Mc Clary, Mariko Nagashima, John Morser, Peter Nawroth, Markus F. Neurath, David Stern, and Ann Marie Schmidt. Rage mediates a novel proinflammatory axis: a central cell surface receptor for S 100/ Calgranulin polypeptides. Cell. 97 889-902, 1999.