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Mark A. Applebaum, MD

Assistant Professor of Pediatrics

Mark Applebaum, MD, is an expert in pediatric cancers and blood diseases. He has a special interest in the treatment of neuroblastoma, sarcomas and solid tumors.

Dr. Applebaum is actively researching several aspects of neuroblastoma and pediatric solid tumors. His research harnesses the power of large genomic data sets in pediatric oncology to develop new "cancer specific" targeted strategies that will ultimately improve outcomes while minimizing risk.

Currently, Dr. Applebaum is focused on how the low oxygen environment of tumors makes cancer cells more resistant to standard therapies. Identifying the genes and cellular pathways responsible for making cancer more aggressive in these conditions may ultimately open new avenues for novel therapeutic options.

Dr. Applebaum's research is supported in part by the University of Chicago Cancer Research Foundation Auxiliary Board. Additionally, he is the recipient of numerous awards, including the Brigid Leventhal Merit Award from the Conquer Cancer Foundation, the Bear Necessities Foundation Young Investigator Award, and the AACR-Aflac Inc. Scholar-in-Training award.

Practice Location

The University of Chicago Medicine
Comer Children's Hospital
5721 S. Maryland Avenue
Chicago, IL 60637

Year Started Practice


Board Certification


Medical School

Northwestern University Feinberg School of Medicine

Internship and Residency

University of California, San Francisco


The University of Chicago Medicine (hematology/oncology, clinical pharmacology and pharmacogenomics)


American Association for Cancer Research
American Society of Clinical Oncology
American Society for Clinical Pharmacology and Therapeutics
American Society for Pediatric Hematology and Oncology

Languages Spoken



Office Phone

(773) 702-6808

Office Fax

(773) 834-1329

Office Postal Address

Mark A. Applebaum, MD
The University of Chicago Medicine
5841 S. Maryland Avenue, MC 4060
Chicago, IL 60637

Clinical Interests

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Selected Publications

View a partial list of Dr. Applebaum's publications through the National Library of Medicine's PubMed online database.