Mark J. Ratain, MD

Leon O. Jacobson Professor of Medicine

Director, Center for Personalized Therapeutics

Associate Director for Clinical Sciences, Comprehensive Cancer Center

Dr. Mark Ratain is an expert in the use of investigational agents to treat advanced solid tumors. He also has a special interest in pharmacogenetics -- the study of how genetic variation affects the body's response to medications.

Dr. Ratain’s research focuses on the development of new oncology drugs, and developing diagnostic tests in order to create individualized anticancer therapies based on each person’s genetic makeup. He is an international leader in phase I clinical trials, pharmacogenetics, and clinical trial methodology. He has more than 235 original publications, leads the University of Chicago’s phase I oncology trials program, and serves as director of the Center for Personalized Therapeutics. Dr. Ratain is also co-chair of the Pharmacogenomics of Anticancer Agents Research (PAAR) Group, which brings together teams of experts from across the nation to investigate advancements in pharmacogenomics.

In 2011, Dr. Ratain was awarded the Translational Research Professorship by the American Society for Clinical Oncology's (ASCO) Conquer Cancer Foundation, and named an honorary fellow by the American College of Clinical Pharmacology.

Practice Locations

University of Chicago Medical Center
5841 S. Maryland Avenue
Chicago, IL 60637

Center for Advanced Medicine
5758 S. Maryland Avenue
Chicago, IL 60637

Year Started Practice

1986

Board Certifications

Clinical Pharmacology
Hematology
Internal Medicine
Medical Oncology

Medical School

Yale University School of Medicine, New Haven, CT

Internship and Residency

Johns Hopkins University, Baltimore, MD

Fellowship

University of Chicago Medical Center

Memberships

American Association for Cancer Research
American Association for the Advancement of Science
American College of Physicians
American Federation for Clinical Research
American Society for Clinical Pharmacology and Therapeutics
American Society of Clinical Oncology
American Society of Hematology
Association of American Physicians
Central Society for Clinical Research
European Society for Medical Oncology

Language Spoken

English

Email

mratain@medicine.bsd.uchicago.edu

Office Phone

(773) 702-6149

Office Fax

(773) 702-3969

Office Postal Address

Mark J. Ratain, MD
University of Chicago Medical Center
5841 S. Maryland Avenue, MC 2115
Chicago, IL 60637

Clinical Interests

• New drug development
• Advanced solid tumors

Request an appointment online
or call HealthLink at
1-888-UCH-0200

Read More About Dr. Ratain

In 2011, Dr. Ratain was awarded the Translational Research Professorship by the American Society for Clinical Oncology's (ASCO) Conquer Cancer Foundation, and named an honorary fellow by the American College of Clinical Pharmacology.

In this ABC7 news story, Dr. Ratain discusses genetic code mapping and the 1200 Patients Project.

Dr. Ratain earned a prestigious grant renewal, which extended his PAAR Group research investigation of unique patient dosing based on genetic factors.

Read more about a study, led by Dr. Ratain, designed to determine a drug's effectiveness in shrinking advanced kidney tumors.

Selected Publications

View a partial list of Dr. Ratain's publications through the National Library of Medicine's PubMed online database.