Mark J. Ratain, MD

Leon O. Jacobson Professor of Medicine

Director, Center for Personalized Therapeutics

Associate Director for Clinical Sciences, Comprehensive Cancer Center

Dr. Mark Ratain is an expert in the use of investigational agents to treat advanced solid tumors. He also has a special interest in pharmacogenetics -- the study of how genetic variation affects the body's response to medications.

Dr. Ratain’s research focuses on the development of new oncology drugs, and developing diagnostic tests in order to create individualized anticancer therapies based on each person’s genetic makeup. He is an international leader in phase I clinical trials, pharmacogenetics, and clinical trial methodology. He has more than 260 original publications, leads the University of Chicago’s phase I oncology trials program, serves as director of the Center for Personalized Therapeutics, and is Chief Hospital Pharmacologist for the University of Chicago Medical Center. Dr. Ratain is also co-chair of the Pharmacogenomics of Anticancer Agents Research (PAAR) Group, which brings together teams of experts from across the nation to investigate advancements in pharmacogenomics.

In 2011, Dr. Ratain was awarded the Translational Research Professorship by the American Society for Clinical Oncology's (ASCO) Conquer Cancer Foundation, and named an honorary fellow by the American College of Clinical Pharmacology. In 2012, Dr. Ratain was named Visiting Professor for the Food and Drug Administration, Center for Drug Evaluation and Research, and Office of Clinical Pharmacology. He also received special recognition from the Department of Pharmaceutics and Pharmaceutical Chemistry from the College of Pharmacy, University of Utah. In 2013, Dr. Ratain was the American Society of Health System Pharmacists Spotlight on Science Featured Speaker.

Practice Locations

The University of Chicago Medicine
5841 S. Maryland Avenue
Chicago, IL 60637

Duchossois Center for Advanced Medicine
5758 S. Maryland Avenue
Chicago, IL 60637

Year Started Practice

1986

Board Certifications

Clinical Pharmacology
Hematology
Internal Medicine
Medical Oncology

Medical School

Yale University School of Medicine

Internship and Residency

Johns Hopkins University, Baltimore, MD

Fellowship

The University of Chicago Medicine

Memberships

American Association for Cancer Research
American Association for the Advancement of Science
American College of Physicians
American Federation for Clinical Research
American Society for Clinical Pharmacology and Therapeutics
American Society of Clinical Oncology
American Society of Hematology
Association of American Physicians
Central Society for Clinical Research
European Society for Medical Oncology

Language Spoken

English

Office Phone

(773) 702-6149

Office Fax

(773) 702-3969

Office Postal Address

Mark J. Ratain, MD
The University of Chicago Medicine
5841 S. Maryland Avenue, MC 2115
Chicago, IL 60637

Physician Photo

Clinical Interests

  • New drug development
  • Advanced solid tumors

Request an appointment online
or call UCM Connect at
1-888-824-0200

Physicians, contact the cancer intake line at (773) 702-8222.

Read More About Dr. Ratain

In 2011, Dr. Ratain was awarded the Translational Research Professorship by the American Society for Clinical Oncology's (ASCO) Conquer Cancer Foundation, and named an honorary fellow by the American College of Clinical Pharmacology.

Under Dr. Ratain’s leadership, a team of researchers are studying the most effective ways to personalize medicine base on each individual’s genotype. Learn more about the 1200 Patients Project.

In this ABC7 news story, Dr. Ratain discusses genetic code mapping and the 1200 Patients Project.

Dr. Ratain earned a prestigious grant renewal, which extended his PAAR Group research investigation of unique patient dosing based on genetic factors.

Read more about a study, led by Dr. Ratain, designed to determine a drug's effectiveness in shrinking advanced kidney tumors.

Selected Publications

View a partial list of Dr. Ratain's publications through the National Library of Medicine's PubMed online database.