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Michael Spiotto, MD, PhD

Assistant Professor of Radiation & Cellular Oncology

Michael Spiotto, MD, PhD, specializes in treating patients with head and neck cancer. Whenever possible, he uses image-guided radiation therapy to target a tumor more precisely while reducing damage to surrounding tissue.

Dr. Spiotto currently serves as the primary investigator on a study examining the role of non-genotoxic inhibitors (agents that slow chemical reactions without damaging genetic tissue) in the spread of head and neck cancers caused by human papillomavirus (HPV). By studying the origin of HPV-induced cancers and understanding how they metastasize, he hopes to develop new treatment protocols and prevent relapse.

An accomplished author, Dr. Spiotto's work has been published in scientific journals such as the Proceedings of the National Academy of Sciences, Immunity, Nature Medicine and Cancer Research. In addition, he has been a the recipient of several notable awards, including: the American Board of Radiology Holman Pathway, given to a trainee with exceptional clinical and research abilities; the University of Chicago's Leon O. Jacobson Basic Science Prize; and the John Van Prohaska Award for outstanding potential in teaching, research and clinical medicine.

Practice Locations

The University of Chicago Medicine
5841 S. Maryland Avenue
Chicago, IL 60637

Center for Advanced Medicine
5758 S. Maryland Avenue
Chicago, IL 60637

Year Started Practice


Medical School

The University of Chicago Pritzker School of Medicine


Memorial Sloan Kettering Cancer Center, New York


Stanford University, Stanford, CA

Additional Graduate Degrees

PhD, University of Chicago (pathology)


American Society of Radiation Oncology
Association of Residents in Radiation Oncology
Radiologic Society of North America

Language Spoken



Office Phone

(773) 702-6870

Office Fax

(773) 834-7340

Office Postal Address

Michael Spiotto, MD, PhD
The University of Chicago Medicine
5841 S. Maryland Avenue, MC 9006
Chicago, IL 60637

Physician Photo

Clinical Interests

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Read More About Dr. Spiotto

Learn more about Dr. Spiotto's research.

Selected Publications

View a partial list of Dr. Spiotto's publications through the National Library of Medicine's PubMed online database.