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Mitchell C. Posner, MD

Thomas D. Jones Professor of Surgery

Chief, Section of General Surgery

Chief, Surgical Oncology

Physician-in-Chief, Comprehensive Cancer Center

With a reputation earned as a leading authority in the management of upper gastrointestinal cancers, Mitchell Posner, MD, ranks among the country's best doctors. Dr. Posner couples his skill as a cancer surgeon with a commitment to multidisciplinary care, providing his patients with optimal outcomes.

Dr. Posner performs surgical procedures for the treatment of gastrointestinal cancers, including:

  • Surgery for pancreatic cancer
  • Whipple procedure
  • Laparoscopic pancreatic surgery
  • Liver surgery for cancer
  • Major hepatic resections
  • Surgery for stomach cancer
  • Surgery for gallbladder and bile duct cancer
  • Surgery for esophageal cancer
  • Surgery for melanoma and sarcoma

Dr. Posner's work goes beyond the operating room. In the lab, he focuses on the molecular basis of malignancies, which has enabled him to design and guide groundbreaking clinical trials for cancers of the pancreas, esophagus, colon, stomach, rectum, and liver. With more than 30 years of experience, he has won dozens of awards and published 250 articles, abstracts, and book chapters.
He has won the University of Chicago's Robert J. Baker Award for Excellence in Teaching, as well as the Basic Science and Clinical Research Award from the Society of Surgical Oncology.
Dr. Posner has held several leadership positions during his distinguished career. He is past-president of the Society of Surgical Oncology. He is deputy editor of the Annals of Surgical Oncology and section editor for the gastrointestinal cancer section of the journal Cancer. He served as chairman of the Gastrointestinal Committee of the American College of Surgeons Oncology Group (ACOSOG).

Practice Locations

Duchossois Center for Advanced Medicine
5758 S. Maryland Avenue
Chicago, IL 60637

Board Certifications

General Surgery
Surgical Oncology

Medical School

State University of New York Buffalo

Internship and Residency

University of Colorado, Denver


Memorial Sloan-Kettering Cancer Center


American Hepato-Pancreato-Biliary Association
American Society of Clinical Oncology
American Surgical Association
Society for Surgery of Alimentary Tract
Society of Surgical Oncology
Society of University Surgeons

Language Spoken



Office Phone

(773) 834-3524

Office Fax

(773) 702-6120

Office Postal Address

Mitchell C. Posner, MD
The University of Chicago Medicine
5841 S. Maryland Avenue, MC 5094
Chicago, IL 60637

Physician Photo

Clinical Interests

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More About Dr. Posner

When she got a grim prognosis for pancreatic cancer, Karen Bluemke turned to UChicago Medicine and Dr. Posner for a second opinion. He performed a Whipple procedure and Bluemke also had chemotherapy. "Dr. Posner was fantastic," she said. "He had so much experience. I went from devastated to hopeful."

Ed Robinson now leads an incredibly robust and productive life after recovering from surgery for advanced stomach cancer. Read Ed's story.

John Hunt is enjoying a new city and a new career after having two gastrointestinal stromal tumors removed by Dr. Posner. Read John's story.

Watch a short video featuring Dr. Posner and an introduction to the Center for Gastrointestinal Oncology.

Selected Publications

View a partial list of Dr. Posner's publications through the National Library of Medicine's Pubmed online database.