Request an Appointment:
Online or Call 1-888-824-0200

Naoum P. Issa, MD, PhD

Assistant Professor of Neurology

Director of Epilepsy Research

Naoum Issa, MD, PhD is a neurologist specializing in the treatment of epilepsy. He works closely with patients to control their epilepsy and is passionate about offering advanced options for epilepsy that is resistant to anti-seizure medications.

Dr. Issa is the director of epilepsy research at the University of Chicago. His research focuses on detecting and diagnosing neurologic disorders using painless, electrophysiological techniques. He and his co-workers are developing ways to identify seizure footprints in deep brain structures without having to implant electrodes.

Dr. Issa has published over 30 scientific papers and book chapters, and is a scientific reviewer for many neurology and neuroscience journals. His work has appeared in journals such as Neurology, Neuron, Nature Protocols, and Journal of Neuroscience.

Dr. Issa serves on the education committee for the department of neurology and has been recognized for his teaching excellence. He has received multiple teaching awards, including L.D.H Wood Preclerkship Teaching Award from the Pritzker School of Medicine.

Practice Locations

University of Chicago Medical Center
5841 S. Maryland Avenue
Chicago, IL 60637

Center for Advanced Medicine
5758 S. Maryland Avenue
Chicago, IL 60637

Year Started Practice


Board Certifications


Medical School

University of Texas - Southwestern


University of Chicago, Northshore


University of Chicago Medicine


University of Chicago Medicine (clinical neurophysiology/EEG)

Additional Graduate Degrees

Ph.D. in Neurobiology, University of Texas - Southwestern


American Association of Neurology
American Epilepsy Society

Language Spoken



Office Phone

(773) 702-6222

Office Fax

(773) 834-4800

Office Postal Address

Naoum P. Issa, MD, PhD
University of Chicago Medical Center
5841 S. Maryland Avenue, MC 2030
Chicago, IL 60637

Physician Photo

Clinical Interests

Request an appointment online
or call UCM Connect at

More About Dr. Issa

Looking for a unique new year's resolution? Dr. Issa recommends getting outside.

Sleep is important for memory and mood. Dr. Issa suggests planning your day to get enough sleep, including naps.

Selected Publications

View a partial list of Dr. Issa's publications through the National Library of Medicine's PubMed online database.