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Peter H. O'Donnell, MD

Assistant Professor of Medicine

Department of Medicine

Peter H. O'Donnell, MD, specializes in the treatment of genitourinary malignancies, including prostate, kidney, and testicular cancers -- with particular expertise in bladder cancer.

Dr. O'Donnell is a well-published researcher with advanced training in pharmacology and pharmacogenomics (the study of genetic traits that cause differences between patients in drug responses and side-effects). He has an interest in the study of personalized medicine, which involves considering each patient's genetic profile when determining chemotherapy and other therapeutic decisions. Dr. O'Donnell has several ongoing research projects. Currently, he is investigating how genetic factors affect chemotherapy drug outcomes -- specifically for patients receiving treatment for bladder cancer, and for patients receiving the widely used chemotherapy drugs cisplatin and capecitabine.

Additionally, Dr. O'Donnell serves as principal investigator of numerous clinical trials, including the "1200 Patients Project," a clinical study operated through the Center for Personalized Therapeutics at the University of Chicago. In this role, he leads an initiative exploring the benefit of incorporating broad pharmacogenomic testing into routine clinical practice for patients with any type of disease.

Dr. O'Donnell is also a member of the University of Chicago Committee on Clinical Pharmacology and Pharmacogenomics. This committee aims to expand the educational mission of conducting research and training the next generation of scientists in clinical pharmacology, principles of therapeutics, molecular pharmacology, and pharmacogenomics.

Practice Location

The University of Chicago Medicine
5841 S. Maryland Avenue
Chicago, IL 60637

Board Certifications

Internal Medicine
Medical Oncology
Clinical Pharmacology

Medical School

The University of Chicago Pritzker School of Medicine


University of North Carolina Hospitals, Chapel Hill, NC

Residency and Fellowship

The University of Chicago Medicine


American Association for Cancer Research
American Society for Clinical Pharmacology and Therapeutics
American Society of Clinical Oncology
American Society of Human Genetics
American Urological Association

Language Spoken


Office Phone

(773) 702-7564

Office Fax

(773) 702-3163

Office Postal Address

Peter H. O'Donnell, MD
The University of Chicago Medicine
5841 S. Maryland Avenue, MC 2115
Chicago, IL 60637

Physician Photo

Clinical Interests

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Learn More About Dr. O'Donnell

Dr. O'Donnell explains to ScienceLife how certain genetic data can play a role in determining the most effective cardiovascular medications.

Dr. O'Donnell is principal investigator of the 1200 Patients Project, an effort to individualize patient care by charting each patient's genetic variations as a guide for treatment.

In this story, Dr. O'Donnell discusses how the 1200 Patients Project will help physicians to improve patient care. Currently, O'Donnell said, "you're treating every patient with the same disease in the same way. We can do better than that."

Selected Publications

View a partial list of Dr. O'Donnell's publications through the National Library of Medicine's PubMed online database.