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Ralph R. Weichselbaum, MD

Daniel K. Ludwig Distinguished Service Professor of Radiation and Cellular Oncology

Chair, Department of Radiation and Cellular Oncology

Dr. Ralph Weichselbaum specializes in the treatment of potentially curative treatment of "oligo" metastasis with radiotherapy.

Dr. Weichselbaum's research interests include mechanisms of tumor spread and how radiation therapy and immunotherapy can be used to better treat cancer. He is also studying patterns of gene expression in human tumors that confer resistance to radiotherapy and chemotherapy. Weichselbaum invented a radio-inducible form of gene therapy TNFerade, which is currently in clinical trials. His research has been funded by the National Institutes of Health for more than 35 years.

He is also editor of Cancer Medicine, a definitive reference textbook compiled to help oncologists and internists apply scientific principles to clinical practice.

Practice Location

The University of Chicago Medicine
5841 S. Maryland Avenue
Chicago, IL 60637

Year Started Practice


Board Certification

Radiation Oncology

Medical School

University of Illinois College of Medicine


Highland-Alameda County Hospital, Oakland, CA

Residency and Fellowship

Harvard Medical School


Institute of Medicine

Language Spoken



Office Phone

(773) 702-0817

Office Fax

(773) 834-7233

Office Postal Address

Ralph Weichselbaum, MD
The University of Chicago Medicine
5841 S. Maryland Avenue, MC 9006
Chicago, IL 60637

Physician Photo

Clinical Interests

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Read More About Dr. Weichselbaum

Dr. Weichselbaum and colleagues report that targeted radiation therapy can control cancer in select patients with cancer that has spread (metastatic disease) to only a few sites.

Dr. Weichselbaum's research team found that some patients with limited numbers of metastasis can be cured using stereotactic body radiotherapy.

Selected Publications

View a partial list of Dr. Weichselbaum's publications through the National Library of Medicine's PubMed online database.