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Shasha Wu, MD, PhD

Assistant Professor of Neurology

Shasha Wu, MD, PhD, specializes in the diagnosis and management of adult epilepsy. Using sophisticated EEG and computer imaging techniques, she works to identify the source of a patient's seizures and determine the best possible course of treatment.

Dr. Wu's current research focuses on the application of Direct Current shift and High Frequency Oscillations in invasive pre-surgical EEG recordings. In the past, she has worked on the ways in which brain trauma -- including stroke and seizure -- affects neurons. Her goal is to improve quality of life for patients experiencing chronic seizures.

Practice Locations

The University of Chicago Medicine
5841 S. Maryland Avenue
Chicago, IL 60637

Duchossois Center for Advanced Medicine
5758 S. Maryland Avenue
Chicago, IL 60637

Year Started Practice


Board Certification

Psychiatry and Neurology

Medical School

Baotou Medical College


AtlantiCare Regional Medical Center, Atlantic City, NJ


Fletcher Allen Health Care, (University of Vermont), Burlington, VT (neurology)


University Hospital, (Case Western Reserve University), Cleveland, OH (neurophysiology/epilepsy)
University of Pittsburgh (neurology research)

Additional Graduate Degrees

PhD, Peking University School of Medicine, Beijing, China


American Academy of Neurology
American Clinical Neurophysiology Society
American Epilepsy Society

Languages Spoken


Office Phone

(773) 834-3894

Office Fax

(773) 834-4800

Office Postal Address

Shasha Wu, MD, PhD
The University of Chicago Medicine
5841 S. Maryland Avenue, MC 2030
Chicago, IL 60637

Physician Photo

Clinical Interests

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Read More About Dr. Wu

When Michael Segreto began to experience troubling seizure activity for the first time in more than 40 years, his physician referred him to Dr. Wu. Learn how Dr. Wu's expertise helped Michael become seizure-free once again.

As a member of the Adult Epilepsy Center, Dr. Wu works with a multidisciplinary team to identify the source of a patient's seizures and determine the best possible solution.

Selected Publications

Wu S, Lüders H et al.  Direct Current Shifts and High Frequency Oscillations (HFO) in Mesial Temporal Lobe Seizures.  (In process).

Li W, Wu S, Ahmad M, Jiang JF, Liu H, Nagayama T, Rose M, Tyurin VA, Chen J, Kagan VE, Graham SH. (2009) The Cyclooxygenase Activity, But Not the Peroxidase Activity of Cyclooxygenase 2 is Required for Neurotoxicity in Hypoxic Ischemic Injury. J Neurochem. 2010 May 113(4):965-77;

Li W, Wu S, Hickey RW, Rose ME, Chen J, Graham SH. (2008) Neuronal Cyclooxygenase-2 Activity and Prostaglandins PGE2, PGD2, and PGF2alpha Exacerbate Hypoxic Neuronal Injury in Neuron-enriched Primary Culture.  Neurochem Res. 2008, Mar; 33(3)490-9;

Tehranian R, Rose ME, Vagni V, Griffith RP, Wu S, Maits S, Zhang X, Clark RS, Dixon CE, Kochanek PM, Bernard O, Graham SH. (2006) Transgenic mice that over express the anti-apoptotic Bcl-2 protein have improved histological outcome but unchanged behavioral outcome after traumatic brain injury. Brain Res.  2006, Jul 26; 1101(1) 126-35.

Wu S.  Zhou L., Xiao X., Rose M., Graham S., (2004). c-FLIP-L Recombinant Adeno-Associated Virus Vector Infection Inhibit Fas-mediated but not NGF withdrawal-mediated Cell Death in PC12 cells. Brain Res Mol Brain Res. 2004 Mar 17; 122(1):79-87.