Stephen L. Archer, MDProfessor of MedicineChief, Section of CardiologyStephen L. Archer, MD, is an internationally known cardiologist and translational physician-scientist. His clinical interests include pulmonary hypertension, persistent ductus arteriosus, strategies for improving cardiovascular care, and training the next generation of physician-scientists. His primary goal at the University of Chicago is creation of a Heart and Vascular Institute, to enhance patient care, research, and education. Dr. Archer's translational cardiovascular research program has two aims: 1) understanding how blood vessels sense oxygen at the molecular level 2) defining the cause of and finding a cure for persistent ductus arteriosus (PDA), a common form of congenital heart disease, and pulmonary arterial hypertension (PAH) a disease of the lung blood vessels that afflicts primarily young women. His research has been recognized with several awards, including the 1996-1997 Visiting Professor of Physiology, awarded by the French Physiologic Society, the Canadian Cardiovascular Society’s 2004 Research Achievement Award and the prestigious Tier 1 Canada Research Chair in Oxygen Sensing and Translation Cardiovascular Research. He is chair-elect of the American Heart Association’s Cardiopulmonary and Critical Care Council. An accomplished author, Dr. Archer has published four books, 34 book chapters, and 160 peer-reviewed articles, most in prominent journals such as Circulation, Circulation Research, the New England Journal of Medicine, The Lancet and the Proceedings of the National Academy of Science. He serves on the editorial boards of several journals, including Circulation Research. Dr. Archer is a dedicated educator, and has mentored many young scientists and physicians who are now themselves leaders in medicine and biomedical research. He has also given more than 200 lectures at universities and scientific meetings around the world. A native of Canada, Dr. Archer served as heart and stroke chair and director of the cardiology division at the University of Alberta before joining the University of Chicago as chief of the Section of Cardiology in 2007. Practice LocationUniversity of Chicago Medical Center
Center for Advanced Medicine
Board CertificationInternal Medicine
Medical SchoolQueen's University Medical School, Kingston, Ontario, Canada InternshipRoyal Columbian Hospital, New Westminster, British Columbia, Canada Residency & FellowshipUniversity of Minnesota, Minneapolis MembershipsAlberta Cardiovascular Society
Language SpokenEnglish sarcher@medicine.bsd.uchicago.edu Office Phone(773) 702-1919 Office Fax(773) 702-8875 Office Postal AddressStephen L. Archer, MD
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Read more about Dr. ArcherRead the press release about Dr. Archer's appointment as chief of the Section of Cardiology. Selected PublicationsBonnet S. et al. 2007, A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 11: 37-51. Archer S.L. 2007, The making of a physician scientist the process has a pattern: lessons from the lives of Nobel laureates in medicine and physiology. European Heart Journal. Bonnet S. et al. 2006, An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension. Circulation.113(22):2630-2641. Weir E.K. et al., 2005, Acute oxygen-sensing mechanisms. N Engl J Med. 353:19:42-55. Archer SL et al 2004 Preferential expression and function of voltage-gated, O2-sensitive K+ channels in resistance pulmonary arteries explains regional heterogeneity in hypoxic pulmonary vasoconstriction: ionic diversity in smooth muscle cells. Circ Res 95:308-318. Michelakis E.D. et al 2003 Long-term treatment with oral sildenafil is safe and improves functional capacity and hemodynamics in patients with pulmonary arterial hypertension. Circulation 108:2066-2069. Michelakis E.D. et al 2002, O2 sensing in the human ductus arteriosus: regulation of voltage-gated K+ channels in smooth muscle cells by a mitochondrial redox sensor. Circ Res 91:478-486. Michelakis E.D. et al 2002, Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels. Circulation 105:244-250. Michelakis E.D. et al 2002, Diversity in mitochondrial function explains differences in vascular oxygen sensing. Circ Res 90:1307-1315. Archer SL et al, 1998, Molecular identification of the role of voltage-gated K+ channels, Kv1.5 and Kv2.1, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes. J Clin Invest 101:2319-2330. |
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