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Bone and Soft Tissue Cancer Care

Bone and soft tissue cancer can be frightening for the children and adults that it strikes. However, the latest treatments available at the University of Chicago Medicine -- from innovative chemotherapy to limb-sparing surgery -- can reduce pain, fight the disease and preserve the ability to walk, work or play.

Multidisciplinary Team, Combination Therapies

Our orthopaedic oncology program includes respected experts in orthopaedic surgery, adult and pediatric oncology, diagnostic and therapeutic radiology, radiation oncology, and pathology. Together, this multidisciplinary team designs the best treatment for patients with bone cancers and soft tissue sarcomas (e.g. synovial sarcomas, liposarcomas, fibrosarcomas).

Bone cancer treatments often combine several types of therapies. We specialize in leading edge care including:

  • Chemotherapy
  • Radiation (external or brachytherapy)
  • Clinical trials of novel therapies, including Phase 1 trials
  • Bone grafting
  • Limb-sparing surgery for even the most difficult-to-remove tumors
  • Computer-assisted surgery which tracks tumor removal in real-time with 3-D X-rays
  • State-of-the-art implants for internal prostheses
  • Bone and joint replacement

Our medical and radiation oncologists provide the most advanced forms of chemotherapy and radiation available. In fact, they are involved in developing, refining and testing the latest drug and radiation treatments.

When surgery is needed, it’s comforting to know that University of Chicago Medicine orthopaedic specialists are nationally recognized for expertise in removing bone and soft tissue tumors and reconstructing the affected limb. Our surgeons are especially skilled at saving limbs when tumors are large or difficult to remove. In all cases, we strive to preserve as much healthy bone, joint surface and tissue as possible. Our goal is to return patients to their maximum function and quality of life.

Pediatric Care

For information about bone cancer and sarcoma care for infants, children, teens and young adults, visit the Pediatric Sarcomas page on the University of Chicago Medicine Comer Children's Hospital website. There you'll find information about the following cancer types:

Transforming Patient Care Through Research

Bone cancer clinical trials

The same specialists who bring comprehensive and compassionate care to patients with bone cancer are working to advance diagnosis and treatment through research. Our database of patients with bone and soft tissue cancer extends back almost four decades, giving us vital information for clinical research in patients with rare tumors.

In our basic science laboratories, investigators are looking at genes that control the spread of cancer and are focusing on new approaches to bone regeneration. These studies could lead to new diagnostic and therapeutic approaches for bone cancer.

Soft tissue sarcoma clinical trials

Our bone cancer program is a core part of the internationally recognized University of Chicago Medicine Comprehensive Cancer Center, one of only two National Cancer Institute (NCI)-designated Comprehensive Cancer Centers in the state. Here, the brightest minds in research are focused on cancer discoveries--working together to bring breakthroughs from the lab to the bedside as quickly as possible.

More Information


  • Benign Bone Tumors, such as Unicameral Bone Cysts, Osteoid Osteoma, and Benign Cartilage Tumors
  • Benign and Malignant Bone and Soft Tissue Tumors
  • Bone Cancer of the Knee, Leg, Arm, Pelvic Area, and Spine
  • Chondrosarcoma
  • Chordoma
  • Ewing Sarcoma
  • Giant Cell Tumor of Bone
  • Malignant Fibrous Histiocytoma
  • Melanoma
  • Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)
  • Osteosarcoma
  • Pathologic Fractures
  • Primitive Neuroectodermal Tumors
  • Primary Bone Cancer
  • Rhabdomyosarcoma
  • Secondary Bone Cancer (Metastatic)
  • Soft-Tissue Sarcomas
  • Synovial Sarcoma

Clinical Trials