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Trilogy System

The University of Chicago Medicine was one of the first health care systems in the United States to treat patients with the Trilogy TM system.

Trilogy gives doctors and patients more options for treatment.

The versatile Trilogy system can be used to deliver the widest range of external beam radiotherapy: 3D conformal radiotherapy, intensity-modulated radiotherapy (IMRT), stereotactic radiosurgery, fractionated stereotactic radiation therapy, intensity-modulated radiosurgery and image-guided radiation therapy (IGRT). This gives doctors--and patients--more options for treatment.

Trilogy is designed to target tumors--even small metastases--with a very high degree of precision. Not only does this mean more effective treatment, it also means fewer side effects--without the risks associated with surgery.

Trilogy System The Trilogy System rotates around the patient to deliver radiotherapy from nearly any angle.

During treatment, the radiation source rotates around the patient to deliver radiation treatments from nearly any angle. Special technology called a multi-leaf collimator allows doctors to "shape" the radiation beam to match the three-dimensional shape of the tumor, and to vary the intensity of the beam in both space and time from each direction (IMRT). The Trilogy system also includes sophisticated cameras that monitor patient movement, such as breathing. This means that radiation is delivered only when the tumor is perfectly aligned to the beam.

How IGRT Works

Prior to treatment, images of a patient’s tumor and the surrounding anatomy are generated (using MRI, CT or PET scanning), and clinicians use this information, along with sophisticated software programs, to prepare a detailed treatment plan.

When the patient arrives for treatment, clinicians use Trilogy’s advanced imaging system to confirm the exact tumor position and make any needed adjustments before treatment begins. Through the use of a respiratory monitoring system that controls the beam delivery, patients can breathe naturally and comfortably during treatment.

Some treatments, primarily for small lesions and metastases, can be accomplished in a single session, while other treatments can be delivered over several shorter sessions.

Technology Comparison

It is critical to recognize that the skill of the radiation oncology team and the excellence of the overall cancer program is as important as the technology in determining patient outcome. The team at the University of Chicago medical center is recognized as one of the best in the country.

The University of Chicago Medicine chose the Trilogy over competing technologies because of its versatility and excellence.

Trilogy Gamma Knife Cyberknife

Continuously adapts to motion caused by breathing




Can treat lesions of any size




Can provide both radiosurgical and conventional radiation treatments




Primary treatment areas



Brain, spine, body

Capable of delivering multiple treatments to reduce damage to surrounding tissues




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